Therapeutics designed to neutralize soluble HIV tat protein could preserve IL-7 signaling and CD8 T-cell function in HIV+ patients
نویسندگان
چکیده
Background Interleukin (IL)-7 signaling is essential to CD8 T-cell development, homeostasis and function, and we have previously shown decreased expression of the IL-7 receptor alpha-chain (CD127) on CD8 T-cells in HIV+ patients. We have also shown that this down regulation of CD127 is mediated in part by soluble HIV Tat protein. By removing the IL-7 receptor from the cell surface, Tat is able to inhibit IL-7 signaling and impair both CD8 T-cell proliferation and cytolytic capacity.
منابع مشابه
IL-7 and the HIV Tat protein act synergistically to down-regulate CD127 expression on CD8 T cells.
IL-7 signaling is essential for optimal CD8 T cell function, homeostasis and establishment of memory. We have previously shown decreased expression of the IL-7 receptor alpha-chain (CD127) on CD8 T cells from HIV-infected patients with active viral replication. We have also shown that soluble HIV Tat protein specifically down-regulates CD127 on the surface of CD8 T cells and impairs cell prolif...
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عنوان ژورنال:
دوره 13 شماره
صفحات -
تاریخ انتشار 2010